The TTC is a pragmatic tool for estimating toxic potential. Both TTC and the Threshold of Regulation (TOR) assign human exposure thresholds to substances with known chemical structure, but unknown toxicity. The dossier reviews the scientific and historical background of threshold concepts and their advantages and challenges.
EFSA guidance on using TTC
EFSA publishes guidance on using the Threshold of Toxicological Concern (TTC) approach in food safety assessment
EFSA: Consultation on TTC guidance
EFSA opens public consultation for guidance on using Threshold of Toxicological Concern in food safety assessment; public comments to be provided until January 8, 2019
Assessment of PPSU for baby bottles
Scientists characterize intentionally and non-intentionally added substances in polyphenylsulfone material intended for baby bottles; analytical results and threshold of toxicological concern-based considerations suggest no safety concerns
Oligomers in PEF polyester
Scientists find ‘abundant’ oligomers in polyethylene furanoate, identify 20 circular and linear oligomer species sized <1000 Da; exact quantities of migrating oligomers to be determined in future investigations
Oligomers in polyester coatings for metal cans
Scientists characterize and quantify monomers and oligomers migrating from different polyester coatings, find migration into real foods compared to food simulants, question predictability of standard migration procedure
Oligomers in PBT and PEN polyesters
Scientists characterize oligomers in polybutylene terephthalate and polyethylene naphthalate intended for food contact; oligomer migration from PBT considered safe based on threshold of toxicological concern considerations
NIAS in polypropylene films
Scientists study migration from food packaging films made of polypropylene; 74 compounds identified, 76% of them NIAS; 35% of samples show migration exceeding either SML or Cramer class-based recommendations
BfR statement on polyamide oligomers
German risk assessment institute evaluates migration of polyamide oligomers from kitchen utensils into food; exposure likely to exceed threshold of toxicological concern; call for more toxicity studies
In vitro bioassays for FCMs
Austrian research institute for chemistry and technology holds information event on bioassays for food contact materials on March 8, 2017 in Vienna