What happens to micro- and nanoplastics in the body?

Study proposes a preliminary physiologically-based toxicokinetic (PBTK) model for micro- and nanoplastics (MNPs); polymer type, size, shape, surface chemistry, surface biofilms, and biocorona determine toxicokinetic rates; models for engineered nanoparticles are not appropriate due to heterogeneity of MNPs; uptake via inhalation and effects of absorbed chemicals need more investigation

Chronic PS nanoplastics exposure found to impact mitochondrial health, impairing cell metabolism

New study examines long-term effects of polystyrene (PS) nanoplastics on mitochondrial health under realistic exposure conditions; repeated exposure to PS nanoplastics impaired mitochondrial function and cell differentiation process, possibly linked to metabolic disorders, such as diabetes and obesity; other recent studies found that PS micro- and nanoplastics negatively affect immune function, pregnancy outcomes, and gut health in various models

Study finds microplastics impact colon cancer cells, could increase metastasis

Study of colon cancer cell lines finds polystyrene micro and nanoplastic particles (MNPs) can be absorbed into cancerous cells in experimental settings; the more aggressive cell line absorbed the most MNPs and presence of MNPs increased cell movement; evidence of persistence and bioaccumulation; authors argue MNPs fit criteria as substance of concern under REACH

Microplastics

Microplastics have been found in all environmental compartments and in biota. Food is one source of human exposure to microplastics, and initial studies have shown that food packaging and processing equipment can contribute to this contamination. Risk assessment of microplastics that is based on exposure and toxicity data is currently hampered by insufficient data.

Uptake of microplastics on the rise – especially in Southeast Asia

Recent studies explore uptake pathways of microplastics; uptake has increased in recent years; rapidly industrializing Southeast Asian countries more impacted; food packaging responsible for approx. 2.98 × 103 microplastics/person/year; higher exposure for regular consumers of bottled water, tea brewed from plastic tea bags, or ultrafiltered milk

Many questions surround microplastics, what about micro(bio)plastics?

Literature review of micro- and nano(bio)plastics research; scrutinizes the complexities of micro- and nano(bio)plastics degradation and their toxicological effects; highlights gaps in long-term impact studies and interactions with environmental conditions; challenges the assumption that “biodegradable” means complete degradation; calls for greater transparency in research practices to bolster collective understanding

Deciphering the differences in plastic particles reported in foods

Two studies investigate micro- and nanoplastics measured in foods; review the range of reported values and diversity of study methods; make suggestions to standardize research methodologies; one study outlines additional standards the micro – nanoplastics research community needs to develop in order to assist regulators

Mapping microplastics in the male reproductive system

Study provides an in-depth look at microplastics in the male reproductive system, analyzes human and mouse samples to chart concentrations and polymer types; finds microplastics in all human testes samples and majority of semen samples; larger plastic particles may get trapped in testis, leading to higher concentrations; identifies correlation between urbanization, home-cooked meals, and body scrub used to microplastics concentration

Studies review human exposures and effects of micro- and nanoplastics

Three studies investigate micro- and nanoplastics – source, organ deposition, and reproductive effects; detect up to 240,000 plastic particles/L in bottled water with 90% being nanoplastics; find microplastics in human lung, intestine, and kidney tissues; polyethylene particles found to affect placental function in mice

Ultra-processed food intake can increase human exposure to phthalates and microplastics

Two studies analyzed ultra-processed foods for phthalates and microplastics; report that consumption of ultra-processed foods and fast food during pregnancy increases exposure to phthalates; link lower socioeconomic status to increased ultra-processed food consumption and phthalate exposure; find highly-processed protein products in the US to contain significantly more microplastics than minimally-processed products; hypothesize plastic processing equipment to be one main source