Topics
mixture toxicity
November 20, 2025
Science policy brief argues that current chemical regulation on single substances underestimates real-world combined chemical exposure and risk; calls for mitigating risks of chemical mixtures by integrating Mixture Allocation Factor (MAF) in revision of EU’s REACH regulation; proposes starting with MAF of five
Topics: mixture toxicity, regulation
Reading time: 2 minutes
June 5, 2025
Make Our Children Healthy Again Assessment aims to summarize US “childhood chronic disease crisis and any potential contributing causes”; Assessment mandated by Executive Order with additional recommendations and strategy forthcoming; part of the Make America Healthy Again (MAHA) project spearheaded by Secretary Robert F Kennedy, Jr.
Reading time: 5 minutes
June 3, 2025
European scientists write an open letter to the European Commission; express that the proposed scope of the REACH revision does not reflect current scientific evidence; call for inclusion of a mixture assessment factor to account for chemical mixtures
Topics: mixture toxicity, REACH
Reading time: 2 minutes
October 17, 2023
Interactive and openly available, the Plastic Health Map summarizes human health outcomes of certain plastic-associated chemicals and particles as published by peer-review articles between 1960 and 2021; includes more than 3500 studies for 1557 chemicals; identifies gaps, including only 30% of chemicals have been investigated for health impacts, few studies in low-income countries
Topics: biomonitoring, chronic disease, exposure, microplastics, mixture toxicity, PFAS, plastics, regulation
Reading time: 4 minutes
September 14, 2023
“How frequent is rare?” researcher asks, emphasizes that based on current knowledge it is “premature” to neglect chemical synergism in real-life mixtures due to being “rare” and limit focus to additive behavior of chemicals; calls for further research and considering synergism in debates on mixtures risk assessment
Topics: mixture toxicity, regulation
Reading time: 1 minute
August 21, 2023
Review describes how cost and disease burden of endocrine-disrupting chemicals (EDCs) can be reduced by policy actions informed by science; recommended solutions include updating testing to account for mixture, cumulative exposure, effects occurring later life; second review summarizes studies linking EDC exposure with immunological and metabolic impacts during pregnancy
Reading time: 3 minutes
November 24, 2022
Study identifies mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) exposure as high-risk factor for leiomyoma growth on epidemiological and mechanistic level; European biomonitoring of five reprotoxic phthalates demonstrates necessity to integrate mixture risk assessment into regulatory practice; targeted analysis shows migration of five phthalates from polypropylene food packaging
Reading time: 7 minutes
October 26, 2022
Researchers develop high-resolution spectral database and method for the identification of 56 selected organic plastic additives; indicates presence of multiple additives when applied to polypropylene and polylactic acid food packaging; highlight chemical signature not polymer but product dependent and “bioplastic” just as conventional plastics contain harmful additives
Reading time: 4 minutes
June 24, 2022
Scientists perform mixture risk assessment on 29 chemicals capable of affecting semen quality; show exposure to chemicals that lead to declined semen quality highly exceed tolerable daily intake in Europe; identify bisphenols, polychlorinated dioxins, paracetamol, and phthalates as risk drivers
Reading time: 2 minutes
May 5, 2022
Author describes the planet’s chemical legacy and emphasizes need for targeted global approach to contend with chemical pollution
Reading time: 2 minutes
