Topics
non-monotonic dose-response
June 24, 2024
A recent study explores the diversity of chemicals migrating from food contact articles into food simulants; 73% of extractable chemicals also migrated to food simulants; only 2% could be matched to currently known plastic chemicals; all migrates activated nuclear receptors, may disrupt metabolism or the endocrine system; migrates from PUR, PVC and LDPE contained more chemicals than other tested polymers and were more toxic
Reading time: 3 minutes
November 2, 2021
European Food Safety Authority (EFSA) publishes opinion on the impact of non-monotonic dose responses (NMDRs) on human health risk assessment; if NMDR may be present, suggests further testing at the low end of the dose-response curve; recommends developing internationally agreed guidance and harmonized frameworks for ‘identifying and addressing’ NMDRs during risk assessments
Reading time: 2 minutes
March 30, 2021
Article in PLOS Biology discusses hazardous chemicals in plastics; highlights chemicals as critical but often missing aspect in plastic pollution discussion; proposes rethinking current approach to plastic packaging toxicity testing
Reading time: 2 minutes
February 4, 2021
Scientific Committee’s Scientific Opinion fails to deliver on European Food Safety Authority’s (EFSA) commitment to scientific excellence and transparency; Food Packaging Forum (FPF) sends open letter to EFSA’s leadership urging them to address severe shortcomings in content and process; adequate scientific appraisal of non-monotonic dose response (NMDR) is critical for chemical risk assessment that protects public health
Reading time: 2 minutes
February 3, 2021
Food Packaging Forum publishes second episode of new video blog; discusses if low levels of chemicals migrating from food packaging are safe; introduces viewers to the concepts of non-monotonic dose response, endocrine disrupting chemicals, mixture toxicity, and timing of exposure
Reading time: 2 minutes
December 17, 2020
European Food Safety Authority’s (EFSA) draft opinion reviews literature on assessment of non-monotonic dose responses (NMDRs), finds lack of standards for statistical approaches; suggests stepwise approach for ambiguous ‘apparent’ NMDRs; approach applied in two case studies finds no NMDR for bisphenol A (BPA) but does for di(2-ethylhexyl)phthalate (DEHP); open for comments until February 4, 2021
Reading time: 2 minutes
June 8, 2020
Food Packaging Forum holds webinar featuring presentation from researchers at Tufts University, discusses recent study observing non-monotonic dose-responses in mammary gland development of rats from exposure to bisphenol A (BPA)
Topics: bisphenol A, non-monotonic dose-response
Reading time: 1 minute
May 22, 2020
Researchers publish study identifying non-monotonic effects on mammary gland development across all ages of rats; finds causal relationship between BPA exposure and effects observed, results counter earlier statements that effects are rather due to random events
Topics: bisphenol A, non-monotonic dose-response
Reading time: 2 minutes
October 29, 2019
Ana Soto presents biological mechanisms underlying non-monotonic dose-responses, explains why non-monotonicity is ‘useful to organisms, challenging for regulators,’ discusses CLARITY-BPA’s successes and limitations
Reading time: 3 minutes
April 5, 2019
European Chemicals Agency to work on authorization applications for octylphenol and nonylphenol ethoxylates; both threshold and non-threshold assessment approaches can be considered
Reading time: 2 minutes
