In a new study published June 4, 2014 in the peer-reviewed scientific journal Environmental Health Perspectives a group of researchers reviewed studies on bisphenol A’s (BPA) toxicity published since 2007 (Peretz et al. 2014). Based on a PubMed search from 2007-2013 the authors conclude that BPA is an ovarian and uterine toxicant. BPA affects the onset of meiosis, interferes with germ cell nest breakdown, accelerates follicle transition, alters steroidogenesis and reduces oocyte quality. It further impairs uterine endometrial proliferation, decreases uterine receptivity and increases implantation failures. They consider that additional studies are required to confirm BPA’s impact on hyperandrogenism, sexual dysfunction and impaired implantation in humans. Research has so far not identified BPA as a testicular toxicant in humans, though animal models show this effect. Peretz and colleagues consider the evidence of effects of BPA on the oviduct, placenta and pubertal development insufficient.
Reference
Peretz, J. et al. (2014). “Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013.” Environmental Health Perspectives (published online June 4, 2014).
