Scientists review migration of nanomaterials from polymer-based FCMs, question suitability of migration testing conditions and diffusion-based models for estimation of nanomaterials migration, point to knowledge gaps regarding actions in human body
December 23, 2016
BPS affects maternal behavior
Exposure of pregnant and lactating mice to human-exposure-relevant dose of bisphenol S (BPS) impairs maternal behavior, what can lead to lower offspring survival; behavioral effects also seen in daughters of exposed mice
December 20, 2016
EFSA on epigenetics in risk assessment
EFSA publishes official report from the June 2016 colloquium on epigenetics in risk assessment
December 2, 2016
ILSI NA workshop on FCMs
Videos of presentations and panel discussions held at ILSI North America workshop on safety evaluation of FCMs in September 2016 are now available online
November 16, 2016
JRC: Report 2016 on alternatives to animal testing
European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) publishes 2016 status report providing an update on its activities
October 26, 2016
EFSA: consultation on MixTox project
European Food Safety Authority calls for stakeholder contributions to shaping its new project MixTox aiming to develop a harmonized methodology for risk assessment of chemical mixtures
October 17, 2016
Five AOPs published by OECD
OECD endorses five new Adverse Outcome Pathways; cover liver fibrosis, heritable mutations, reproductive dysfunction, impairment of learning and memory abilities in children and adults; new background article on AOPs available on FPF website
October 17, 2016
Adverse outcome pathways
Adverse outcome pathway (AOP) describes the sequence of events linking initial molecular perturbations to adverse outcomes in organisms and populations; this framework supports the use of high-throughput animal-free toxicity testing methods in regulatory decision-making
October 7, 2016
Adverse health effects of low-dose mixtures
Scientists evaluate health effects of a mixture of 27 environmental chemicals in rats exposed to low concentrations comparable to current human exposure levels; find effects on weight, histology, gene expression in the liver, and metabolome of blood plasma
September 20, 2016
BfR’s research on nanomaterials
German Institute for Risk Assessment (BfR) summarizes its research on health and environmental safety of nanomaterials and other novel materials; nanoparticle detection optimized in different matrices; animal-free toxicity testing implemented
