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Scientists review studies demonstrating differences in drug pharmacokinetics between young and elderly people, recommend use of varying uncertainty factors for acceptable daily exposure calculations due to sensitivity differences
Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines
U.S. Food and Drug Administration hosts webinar on guideline studies conducted within CLARITY-BPA program, September 13, 2018; registration now open
Review of perchlorate’s human health effects finds ‘mixed results’ regarding neurodevelopment; Austrian assessment of dietary perchlorate exposure finds exceedance of tolerable daily intake levels for high consumption; recent studies address effects in newborns, other effects
Scientists highlight BPA’s interactions with multiple molecular targets besides estrogen receptor; growing body of evidence demonstrates similar pleiotropic actions of BPA substitutes such as BPS, BPF, BPAF and others
Minutes from recent meetings of the EFSA working groups on BPS, BPA, FCMs, phthalates, and recycling plastic available
On the morning of the Food Packaging Forum’s 11th annual workshop, speakers share processes to measure sustainable food packaging while accounting for multiple concerns; three speakers share findings from developing frameworks to make packaging safer, account for tradeoffs, and reduce plastic packaging use; three speakers share how policy is developed at the United Nations and European Union
EU Working Group on FCMs discusses BPA, amendments to EU 10/2011, mineral oil migration, authorization of recycling processes, migration testing guidelines
Group of scientists calls for maintaining chemical regulation’s status quo; toxicologist and pharmacologist express concern that the forthcoming EDC regulation will not be based on science and erase established risk assessment approaches
Ana Soto presents biological mechanisms underlying non-monotonic dose-responses, explains why non-monotonicity is ‘useful to organisms, challenging for regulators,’ discusses CLARITY-BPA’s successes and limitations
