EHP publishes a letter to Gayrard et al. and the researchers’ response, points to differences in BPA exposure throughout the body
India updating ionomer resin standard
Bureau of Indian Standards publishes draft update to standard for ionomer resins in contact with foodstuffs, pharmaceuticals, and drinking water; accepting comments on the proposal until December 6, 2022
Evidence evaluation in risk assessment: Detailed guidance needed
Weight-of-evidence evaluation and systematic review methods are promoted in most chemical risk assessment frameworks in the EU, but clear guidance is lacking; scientists suggest joint guidance development by EU agencies dealing with chemicals
Chemical metabolism in young and elderly
Scientists review studies demonstrating differences in drug pharmacokinetics between young and elderly people, recommend use of varying uncertainty factors for acceptable daily exposure calculations due to sensitivity differences
RIVM studies argue applied maximum doses too low
Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines
Webinar on CLARITY-BPA core study
U.S. Food and Drug Administration hosts webinar on guideline studies conducted within CLARITY-BPA program, September 13, 2018; registration now open
Health effects of perchlorate exposure
Review of perchlorate’s human health effects finds ‘mixed results’ regarding neurodevelopment; Austrian assessment of dietary perchlorate exposure finds exceedance of tolerable daily intake levels for high consumption; recent studies address effects in newborns, other effects
BPA and analogues: Multiple targets and effects
Scientists highlight BPA’s interactions with multiple molecular targets besides estrogen receptor; growing body of evidence demonstrates similar pleiotropic actions of BPA substitutes such as BPS, BPF, BPAF and others
Restaurant food likely source of phthalate exposure
New study evaluates NHANES data and finds link between food consumption at restaurants, cafeterias, fast-food outlets and increased urinary phthalate levels
Chemical characterization of post-consumer and recycled plastics
Scientists perform target and non-target screening of recycled plastics and provide recommendations on methods; detect >280 organic chemicals and metals in 21 plastic flakes and pellets used in recycling; analyze several recycled polymers and find polyethylene terephthalate (PET) the only one currently complying with European circular economy requirements; compare analytical methods to assess the chemical composition of recyclates giving their strenghts and limitations