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Aggregate exposure assessment for BPA

Scientists discuss aggregate exposure assessment for bisphenol A; source-to-dose (forward) and biomonitoring-based (backward) calculation resulted in similar estimates; 90% of exposure comes from diet and the remaining 10% mainly from dermal exposure

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Petition calls for US FDA to consider cumulative effects

Coalition requests US Food and Drug Administration (FDA) to follow its own mandate to consider cumulative effects of chemicals present during safety assessments; covers chemicals directly added to food, substances migrating from food packaging, substances generally recognized as safe (GRAS); finds only 1 of 877 existing GRAS notifications adhered to requirement

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Second study finds microplastics in human placenta

Clinical study investigates 10 microplastic types in human placenta and meconium; detects polyethylene, polypropylene, polystyrene, and polyurethane in the samples; highlights that evaluation and control of potential contamination is crucial

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Evaluation framework for new approach methodologies

Multistakeholder study presents framework to evaluate new approach methodologies for assessing safety of chemicals; uses three steps and set of core principles, criteria to check if fit-for-purpose; provides case studies illustrating application