Special issue of Toxicology and Applied Pharmacology features 18 articles discussing alternative (non-animal) methods for assessing chemicals’ potential to harm neurodevelopment in children
Studies present new generic and specific modeling approaches for FCCs migration
Scientists develop nonlinear model for predicting food contact chemical (FCC) migration and apply it to FCCs of high toxicological concern; emphasize usefulness of their model to speed up migration assessment of FCCs; different group of scientists proposes an innovative modeling approach to assess release of a specific additives and elements from plastic food packaging and steel processing tools
Detecting WEEE contamination in recycled FCM plastics
Scientists propose procedure for detection of contaminants from waste electric and electronic equipment (WEEE) in FCMs made of recycled plastics; call for regular screening to be performed by authorities to ensure compliance
BPA and analogues: Multiple targets and effects
Scientists highlight BPA’s interactions with multiple molecular targets besides estrogen receptor; growing body of evidence demonstrates similar pleiotropic actions of BPA substitutes such as BPS, BPF, BPAF and others
India bans PET for certain pharmaceuticals
India phases out PET and other plastic bottles as packaging for medicinal products for pediatric, geriatric use and for use by women in the reproductive age
Health effects of perchlorate exposure
Review of perchlorate’s human health effects finds ‘mixed results’ regarding neurodevelopment; Austrian assessment of dietary perchlorate exposure finds exceedance of tolerable daily intake levels for high consumption; recent studies address effects in newborns, other effects
Focus on EDC controversy
Health & Environment article outlines debate around 2012 WHO/UNEP report on EDCs; discusses value of state-of-the-science reviews and need for systematic review methods in complex research problems
Food packaging chemicals in ToxCast
Scientists use ToxCast data to prioritize food-relevant chemicals for safety testing; identify obesity- and diabetes-related chemicals, and chemicals affecting growth and development; multiple food contact chemicals found to be active in ToxCast assays
Parabens increase BPA exposure
Parabens inhibit several biotransformation enzymes involved in steroid hormone metabolism and chemical detoxification; study in mice shows that co-exposure with butyl paraben results in elevated internal levels of estradiol and BPA
NIAS migration from plastic wine corks
Scientific study uses non-targeted chemical analysis to provide an overview of chemicals migrating from 8 wine corks made of ethylene-vinyl acetate; identifies 50 compounds, 84% non-intentionally added substances (NIAS); finds one cork not suitable as food contact material