New research from the Food Packaging Forum looks at food contact chemicals (FCCs) that have been detected in humans; compares known FCCs with human biomonitoring programs, metabolome/exposome databases and the scientific literature; 3,601 FCCs have evidence of presence in humans, including chemicals with hazardous properties; comes with interactive dashboard to browse all data
Systematic review finds evidence “robust” that BPA reduces semen quality
Scientists review the association between bisphenol A (BPA) exposure and declines in semen quality based on animal and epidemiological studies; assess weight of evidence of associations and estimate BPA reference dose of 0.003 µg/kg/d for male reproductive health for use in mixture risk assessments
Threshold of Toxicological Concern (TTC) for risk assessment of food contact material chemicals
The Threshold of Toxicological Concern, short TTC, is a concept for assessing the risk of single chemical exposure to human health. It establishes generic exposure thresholds based on chemical structure below which chemicals are assumed to be safely used. In the absence of toxicological data, regulators, academic scientists and industry experts are using the TTC to perform chemical risk assessments. On October 17, 2013 the Food Packaging Forum held a workshop offering a platform for balanced information and scientific debate […]
Parabens increase BPA exposure
Parabens inhibit several biotransformation enzymes involved in steroid hormone metabolism and chemical detoxification; study in mice shows that co-exposure with butyl paraben results in elevated internal levels of estradiol and BPA
Studies review human exposures and effects of micro- and nanoplastics
Three studies investigate micro- and nanoplastics – source, organ deposition, and reproductive effects; detect up to 240,000 plastic particles/L in bottled water with 90% being nanoplastics; find microplastics in human lung, intestine, and kidney tissues; polyethylene particles found to affect placental function in mice
Mineral oils: Toxicity, exposure possibly underestimated
Scientific study compares accumulation of mineral oil saturated hydrocarbons (MOSH) in rats to humans; findings imply that current acceptable daily intake for MOSH may be set too high and current human exposure is underestimated
Microplastics in humans: current knowledge and potential implications
Review summarizes microplastics abundance and characteristics in human biological samples including current research approaches employed, challenges, and prospects; study indicates microplastics impact human meconium and placenta microbiota; review outlines current evidence on microplastic effects upon exposure during early developmental stage
Currently used tiered approach not adequate for substances with non-monotonic dose-response
EFSA publishes report on Low Dose Colloquium in June
Viewpoint: Subthreshold effects need consideration in chemical risk assessment
Scientists point out chemical risk assessments worldwide neglect current scientific knowledge; advocate to consider potential subthreshold effects in regulatory risk assessment
TBBPA and triclosan cause higher BPA exposure
Mice study shows that co-exposure with tetrabromobisphenol A and triclosan alters toxicokinetics of BPA, results in elevated tissue levels